ABSTRACT
Objective@#To investigate the significance of circulating tumor cells (CTC) in squamous cell carcinoma of the head and neck (HNSCC).@*Methods@#Twenty-four patients with HNSCC treated between October 2016 and July 2017 in our department were selected (experimental group), including 23 males and 1 females, aged 47-81 years. There were 14 cases of squamous cell carcinoma of larynx and 10 cases of hypopharynx, including I-Ⅱ stage (5 cases) and Ⅲ- Ⅳ stage (19 cases). All patients were primary and/or relapsed after treatment. Nine healthy volunteers were selected as control group. A novel in vivo capture technique (CellCellector system) was used to detect CTC. SPSS23.0 was used for statistical analysis.@*Results@#The total capture rate of CTC in patients with HNSCC before treatment was 70.8% (17/24), with 40% (2/5) for patients at I-Ⅱ stage, and 78.9% (15/19) for patients at Ⅲ- Ⅳ stage, and was 0 in patients of control group. The total capture rate of CTC in patients with HNSCC after treatment was 50% (8/16). There was no significant correlation between CTC and age, sex, location of tumor or lymph node metastasis (P>0.05). CTC was related to tumor staging and tumor differentiation (P<0.05). The positive rate of EGFRVⅢ in CTC was 26.3% (5/19).@*Conclusions@#The CellCollector system is a very efficient way of detecting CTC, and CTC plays an important role in the occurrence, progression and metastasis of HNSCC.
ABSTRACT
Objective To observe the correlation between postoperative sputum properties and pharyngeal fistula in laryngeal cancer patients and summarize the nursing points. Methods Fifty laryngeal cancer patients with partial laryngectomy but no radio-therapy were enrolled in the study to record the sputum properties change,pharyngeal fistula.The relevant care measures were taken. Results On day 3 to 5 after partial laryngectomy,the sputum from the patients was stickier and more odorous,and the stench intensity was increased.1 case and another 7 ones were diagnosed as pharyngeal fistula on days 3 and 7,respectively.3 of them were healed by local open medication for 2 to 4 weeks.The other 5 cases which were not cured with routine medication for 4 to 6 weeks were treated with repair of pectoralis major myocutaneous flap and then healed on days 10 to 104 days,averaged (56.03 ±16.87)d. Conclusions The postoperative sputum properties like color,stickiness and odor can indicate the local healing condition.The relevant nursing mea-sures can promote their recovery.